proliferative – Communicable Diseases Research

SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice

Article

Published on 2022-09-282022-11-15
Journal: Science Translational Medicine
[Category] SARS, 치료제,

Humoral and cellular responses to SARS-CoV-2 BNT162b2 vaccination in allogeneic hematopoietic stem cell transplantation recipients

동종 조혈모세포 이식 환자에서 SARS-CoV-2 BNT162b2 백신 접종에 대한 체액 및 세포 반응

Article

Published on 2022-08-052022-09-11
Journal: Vaccine
[Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

[키워드] Allogeneic anti-S IgG anti-S IgG levels assays baseline BNT162b2 both group both groups CD4 cellular cellular response Cohort correlation defined detectable doses ELISpot assay evaluated exhibited FIVE flow cytometry group humoral Humoral and cellular responses Humoral response IFNγ IgG level Immunosuppressive treatment lymphocyte mRNA vaccination Neutralizing antibodies neutralizing antibody not significantly different Patient percentage Previous studies previous study proliferation proliferative prospectively studied recipient Responder SARS-CoV-2 SARS-CoV-2 BNT162b2 seroconverted serological Stem cell transplantation T cell T cells Two patient vaccination Vaccine
[DOI] 10.1016/j.vaccine.2022.07.006 PMC 바로가기 [Article Type] Article

Proliferative glomerulonephritis with monoclonal immunoglobulin deposits triggered by COVID-19: a case report

COVID-19에 의해 유발된 단일클론 면역글로불린 침착을 동반한 증식성 사구체신염: 증례 보고

Case Reports

Published on 2022-08-012022-09-12
Journal: CEN case reports
[Category] MERS, 진단,

Longitudinal Assessment of SARS-CoV-2-Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multicytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity

1년 동안 SARS-CoV-2-특이적 T 세포 사이토카인 생성 반응에 대한 종단 평가는 질병 중증도와 관련된 더 큰 면역과 함께 다중 사이토카인 증식 반응의 지속성을 보여줍니다

Article

Published on 2022-07-132022-09-11
Journal: Journal of Virology
[Category] COVID19(2023년), SARS, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 all subjects assessment average CD4 CD8 Cell Cell-mediated immunity clone coronavirus Coronaviruses Critical cytokine cytokine response Cytokines declined demonstrated dominant ELISPOT ELISpot assay envelope enzyme-linked immunosorbent epitope Epitopes Ex vivo female Frequency gamma interferon granzyme B greater GzmB highlight IFN-γ IL-2 immune immune modeling. Immunity immunodominant immunodominant epitope immunodominant epitopes induce Infection interferon interleukin interleukin 2 kill longitudinal male median membrane nucleocapsid observation other coronaviruses peaked persistence post-symptom onset potent predicted produced producing proliferative PSO reduced regions response robust SARS-CoV-1 SARS-CoV-2 seasonal coronavirus seasonal coronaviruses severe acute respiratory syndrome Coronavirus severe disease structural protein structural proteins subject survivor T cell T cell immunity T cell memory T cell response T cell responses T cells target cells Vaccine viral infections Year
[DOI] 10.1128/jvi.00509-22 PMC 바로가기 [Article Type] Article

Single-cell transcriptomic profiling of lung endothelial cells identifies dynamic inflammatory and regenerative subpopulations

폐 내피 세포의 단일 세포 전사체 프로파일링은 동적 염증 및 재생 하위 집단을 식별합니다

Article

Published on 2022-06-082022-09-11
Journal: JCI Insight
[Category] COVID19(2023년), SARS, 신종인플루엔자, 유전자 메커니즘,

[키워드] Activation Bacterial infections baseline Cell Clustering defined demonstrated division endothelial endothelial cells Endothelium expression Gene Expression H1N1 H1N1 influenza H1N1 influenza virus heterogeneity identify immune response gene immune response genes increased expression infected with SARS-CoV-2 Infectious disease Inflammatory inflammatory lung injury inflammatory signaling Influenza Injury labor limit LPS lung lung endothelial Lung injury MHC gene MHC genes murine organ overexpression Pathway analysis performed phenotypic prevented proliferative promote Pulmonology Pulmonology. regeneration regenerative respond Seurat single-cell single-cell RNA-seq Sox17 subpopulation targeted therapy transcriptomic Vascular vascular bed vascular endothelial cell vascular endothelial cells virus
[DOI] 10.1172/jci.insight.158079 PMC 바로가기 [Article Type] Article

The Humoral Immune Response of the ChAdOx1 nCoV-19 Vaccine in Maintenance Dialysis Patients without Prior COVID-19 Infection

Article

Published on 2022-02-212022-10-28
Journal: Vaccines
[Category] COVID-19,

[키워드] age anti-receptor-binding-domain antibody antibody Antibody Response AZ vaccine B cell blood test ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 (Oxford-AstraZeneca, AZ) vaccine chronic Chronic dialysis CKD COVID-19 COVID-19 vaccine cytometry analysis delayed response dialysis dose Efficacy eight evaluated first vaccination Flow immune immune response Infection Kidney disease maintenance Oxford-AstraZeneca participant Patient performed positive positive antibody response proliferative RBD reduced responders response SARS-CoV2 significantly lower Spike protein the receptor-binding domain the S1 subunit the SARS-CoV-2 vaccination Vaccine
[DOI] 10.3390/vaccines10020338 PMC 바로가기 [Article Type] Article

DExD/H-box helicase 9 intrinsically controls CD8 + T cell-mediated antiviral response through noncanonical mechanisms

DExD/H-box 헬리카제 9는 비정규 메커니즘을 통해 본질적으로 CD8 + T 세포 매개 항바이러스 반응을 제어합니다

Article

Published on 2022-02-112022-09-11
Journal: Science Advances
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제,

Epigenomic and transcriptomic analyses reveal differences between low-grade inflammation and severe exhaustion in LPS-challenged murine monocytes

Article

Published on 2022-01-282022-10-04
Journal: Communications Biology
[Category] 바이오마커,

Identification of potentially anti-COVID-19 active drugs using the connectivity MAP

연결 맵을 사용하여 잠재적으로 항 -CovID-19 활성 약물의 확인

Research Article

Published on 2022-01-272022-09-10
Journal: PLoS ONE
[Category] SARS, 신약개발, 유전자 메커니즘, 치료제,

[키워드] activating AMPK Analysis Anti-inflammatory applied Cancer cells catabolic Cell characterization Compound connectivity coronavirus coronavirus disease Coronavirus disease-19 COVID-19 Cyclooxygenase database deleterious effect deleterious effects Dexamethasone drug Drug repurposing emergency response favor fluorometholone gene expression profile Gene expression profiles generate glucocorticoid Glucocorticoid receptor growth identification identify infected cells interfere involved lipid metabolism Map MDM2 metabolism modulate nitric oxide nitric oxide synthase organism Other other compounds Oxide p53 pandemic pathway proliferative reaction receptor resource respiratory Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 Signaling tissue Transmission treat virus
[DOI] 10.1371/journal.pone.0262751 PMC 바로가기 [Article Type] Research Article

Paternally expressed gene 3 ( Pw1/Peg3 ) promotes sexual dimorphism in metabolism and behavior

친밀하게 발현 된 유전자 3 (PW1/PEG3)은 신진 대사와 행동에서 성 이형성을 촉진합니다

Research Article

Published on 2022-01-132022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] accelerated Adiposity adulthood age allele alteration Behavior Brain Cell cells Characteristics consequence contribute develop Diabetic Endocrine Epigenetic examined expressed expressing fat accumulation Fatty liver female genomic genomic imprinting gonadal growth hormone insulin insulin resistance life loss of function male mammal mammals manifested masculinization metabolism mice mutant observation parental pathway Peg3 phenotypic postnatal development proliferative promote provide puberty question reduced Regulation selective Sex sex steroid sexual dimorphism Signaling steroid Support tissues weaning
[DOI] 10.1371/journal.pgen.1010003 PMC 바로가기 [Article Type] Research Article